Questioning the source of
nonspecific hyperinflammation?

It could be HLH/MAS


Macrophage activation syndrome (MAS) is a rare and potentially fatal syndrome that can occur in patients with underlying rheumatic disease. MAS is characterized by interferon gamma (IFNγ)-hyperactivated macrophages that release an uncontrolled surge of proinflammatory cytokines leading to life-threatening hyperinflammation.1-3

Find out how to identify this syndrome of dangerous immune dysregulation in your patients before it’s too late.

Female MAS patient highlighted
Multisystem distress risk icon

MULTISYSTEM DISTRESS4-7

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MULTISYSTEM DISTRESS4-7

General malaise icon

Signs of general malaise

: High fever 102°F temperature icon

Persistent high fever

Central nervous system involvement brain icon

Central nervous system involvement

Rash icon

Rash

Liver icon

Hyperferritinemia
Hepatosplenomegaly
Hypertriglyceridemia

Coagulopathies icon

Coagulopathies

This is not an exhaustive list of MAS signs and symptoms. Presentation may vary between patients, and it is not necessary to identify all of these symptoms to diagnose MAS.

Macrophage activation syndrome (MAS) is a rare and potentially fatal syndrome that can occur in patients with underlying rheumatic disease. MAS is characterized by interferon gamma (IFNγ)-hyperactivated macrophages that release an uncontrolled surge of proinflammatory cytokines leading to life-threatening hyperinflammation.1-3

Find out how to identify this syndrome of dangerous immune dysregulation in your patients before it’s too late.

References: 1. Schulert GS, Grom AA. Macrophage activation syndrome and cytokine-directed therapies. Best Pract Res Clin Rheumatol. 2014;28(2):277-292. doi:10.1016/j.berh.2014.03.002 2. Crayne C, Cron RQ. Pediatric macrophage activation syndrome, recognizing the tip of the iceberg. Eur J Rheumatol. 2020;7(Suppl1):S13-S20. doi:10.5152/eurjrheum.2019.19150 3. Di Cola I, Ruscitti P, Giacomelli R, Cipriani P. The pathogenic role of interferons in the hyperinflammatory response on adult-onset Still’s disease and macrophage activation syndrome: paving the way towards new therapeutic targets. J Clin Med. 2021;10(6):1164. doi:10.3390/jcm10061164 4. Lerkvaleekul B, Vilaiyuk S. Macrophage activation syndrome: early diagnosis is key. Open Access Rheumatol. 2018;10:117-128. doi:10.2147/OARRR.S151013 5. Sen ES, Clarke SL, Ramanan AV. Macrophage activation syndrome. Indian J Pediatr. 2016;83(3):248-253. doi:10.1007/s12098-015-1877-1 6. Monteagudo LA, Boothby A, Gartner E. Continuous intravenous anakinra infusion to calm the cytokine storm in macrophage activation syndrome. ACR Open Rheumatol. 2020;2(5):276-282. doi:10.1002/acr2.11135 7. Avau A, Matthys P. Therapeutic potential of interferon-γ and its antagonists in autoinflammation: lessons from murine models of systemic juvenile idiopathic arthritis and macrophage activation syndrome. Pharmaceuticals (Basel). 2015;8(4):793-815. doi:10.3390/ph8040793