Do nonspecific symptoms have you
questioning the diagnosis?

It could be primary HLH

Primary hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal syndrome characterized by a rapidly progressive state of maladaptive hyperinflammation. It presents with a range of nonspecific signs and symptoms of multisystem distress that can overlap with other conditions, making the diagnostic process difficult.1 Find out how to identify this dangerous immune dysregulation in your patients before it’s too late.

Primary HLH patient highlighted
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MULTISYSTEM DISTRESS1

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MULTISYSTEM DISTRESS1

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Persistent high fever

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Central nervous system involvement

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Rash

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Hyperferritinemia
Hepatosplenomegaly
Hypertriglyceridemia

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Cytopenias

Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal syndrome characterized by a rapidly progressive state of maladaptive hyperinflammation. It presents with a range of nonspecific signs and symptoms of multisystem distress that can overlap with other conditions, making the diagnostic process difficult.1 Find out how to identify this dangerous immune dysregulation in your patients before it’s too late.

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Pathophysiology of primary HLH

Learn about the mechanisms of immune dysregulation in primary HLH.

What happens in primary HLH?
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Signs and Symptoms

See how primary HLH can manifest in patients.

Learn the signs
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Diagnosing primary HLH

Explore the diagnostic process for primary HLH.

How to diagnose primary HLH

Reference: 1. Jordan MB, Allen CE, Weitzman S, Filipovich AH, McClain KL. How I treat hemophagocytic lymphohistiocytosis. Blood. 2011;118(15):4041-4052. doi:10.1182/blood-2011-03-278127